Cd112 antibody

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August undefined, 2024

WebDetection of Mouse Nectin‑2/CD112 by Western Blot. Western blot shows lysates of C2C12 mouse myoblast cell line and NIH-3T3 mouse embryonic fibroblast cell line. PVDF Membrane was probed with 1 µg/mL of Mouse Nectin-2/CD112 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3869) followed by HRP-conjugated Anti-Sheep IgG … WebCD112R is a cell surface receptor for CD112/Nectin-2, it compete against CD226 in binding to CD112. Following interaction with CD112, CD112R inhibits T-cell proliferation and the disruption of interaction between CD112R and CD112 enhances T cell response.

Purified anti-human CD112R (PVRIG) Antibody, CD112R, W16216D

WebAbout This Program. This program aims to develop anti-CD112 therapeutic monoclonal antibody for immuno-oncology. CD112 acts as an organizer for Sertoli and sperm cell … WebCD112, known as poliovirus receptor related 2 protein (PRR2), Nectin-2, or Hve B, is a type I transmembrane glycoprotein, a member of the Ig gene superfamily. It is primarily found on myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34 positive stem cells, endothelial cells, epit camping sites near golspie

CD112 Antibody, anti-human, REAfinity™ - Miltenyi Biotec

WebCD112 is a type I transmembrane glycoprotein that is encoded by NECTIN2 (Nectin cell adhesion molecule 2) which belongs to the Ig gene superfamily. CD112 is also … WebCells were incubated with an excess of purified unconjugated CD112 (REA1195) antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or ... WebNectin 2 encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading ... camping sites near gordons bay

A reporter gene assay for determining the biological activity of ...

The CD112R/CD112 axis: a breakthrough in cancer …

WebAbout This Program. This program aims to develop anti-CD112 therapeutic monoclonal antibody for immuno-oncology. CD112 acts as an organizer for Sertoli and sperm cell junctions and synapse formation in testis and neurons. In addition to the cell adhesion function, CD112 mediates the entry and spread of infections from various viruses. Web1.一种嵌合抗原受体，其包含配体结合结构域、跨膜结构域、共刺激结构域和胞内信号传导结构域，其中所述共刺激结构域包含nk激活性受体或其配体的胞内区，其中所述nk激活性受体选自2b4、dnam‑1和lfa‑1，所述nk激活性受体的配体选自cd48、cd112、cd155、icam1、icam2和icam3。 camping sites near jasperWebDetects human Nectin‑2/CD112 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human (rh) Nectin-1, rhNectin-3 and rhNectin-4 is observed. Test in a species/application not listed above to receive a full credit towards a future purchase. camping sites near heidelberg gauteng

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Cd112 antibody

WebCD112R is a cell surface receptor for CD112/Nectin-2, it compete against CD226 in binding to CD112. Following interaction with CD112, CD112R inhibits T-cell proliferation and the disruption of interaction between CD112R and CD112 enhances T cell response. Published studies suggest that CD112R is a novel co-inhibitory receptor, or a checkpoint ... WebRequest Bulk Quote. Description. CD112, known as poliovirus receptor related 2 protein (PRR2), Nectin-2, or Hve B, is a type I transmembrane glycoprotein, a member of the Ig …

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WebSep 10, 2024 · CD112 is easily detectable on antigen-presenting or tumor cells, and its high level of expression has been linked with tumor progression and poor outcomes in … WebOct 28, 2014 · Blots were probed with antibodies specific for CD112, CD155, and gD as well as for gB and gC (infection controls) and tubulin (loading control). As shown in Fig. S1 A , WT PRV-infected cells showed substantially reduced CD112 protein levels compared with mock-infected cells or cells infected with gDnull PRV, whereas CD155 protein levels …

WebBackground: Nectin-2/CD112 Nectins are a small family of Ca ++-independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs) that control cell adhesion, proliferation, and migration (1, 2, 3).The name Nectin derives from the Latin word necto, which means “to connect”.The Nectin family contains four members (Nectin-1 to -4), all … WebAnti-human CD112 antibody (Purple Squares, Clone TX31) inhibits the binding in a dose-dependent manner whereas the isotype control (Green Triangles, Cat. No. 400193) does not have this effect. This antibody blocks the binding of 15 µg/mL recombinant human CD112R protein to 1 µg/mL of immobilized recombinant human CD112 with an ND 50 = 0.8 - 5 ...

WebThere are no reviews for Nectin-2/CD112 Antibody (FAB2229B). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount. Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen; Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen; Submit a Review. Product General Protocols ... WebJan 15, 2024 · An antibody-based blockade of CD112 also significantly reduced T cell transmigration across endothelial monolayers in vitro. Moreover, T cell homing to the spleen was significantly reduced in CD112-deficient mice. Overall, our results identify CD112 as a regulator of angiogenic processes in vivo and demonstrate a novel role for CD112 in T …

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WebDescription. CD112 antibody LS-C183000 is an FITC-conjugated rat monoclonal antibody to CD112 (PVRL2) (Extracellular Domain) from mouse. It is reactive with human and mouse. Validated for ELISA, IHC, IP and WB. fischergasse speyerWebCD112 (Nectin-2) can serve as a ligand for CD226 (DNAM-1) that is involved in NK and T cell-mediated cytotoxicity against certain target cells including certain tumors. The CD112 (Nectin-2) protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell-to-cell spreading of ... fischer gasthofWebMonoclonal Antibody for studying nectin 2. Cited in 3 publications. Validated for Western Blotting, Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Nectin … camping sites near lands endWebScientific Data. Detection of Nectin-2/CD112 in C2C12 Mouse Cell Line by Flow Cytometry. C2C12 mouse myoblast cell line was stained with Rat Anti-Mouse Nectin-2/CD112 Monoclonal Antibody (Catalog # MAB3869, … camping sites near hyderabadWebCD112, known as poliovirus receptor related 2 protein (PRR2), Nectin-2, or Hve B, is a type I transmembrane glycoprotein, a member of the Ig gene superfamily. It is primarily found on myelomonocytic cells, megakaryocytes, dendritic cells, mast cells, CD34 positive stem cells, endothelial cells, epithelial cells, and neuronal cells. fischergasse solothurnWebDec 1, 2024 · The positive clone CHO-CD112-CD3 scFv-1B5 that showed upregulated expression of CD112 and CD3 scFv on its cell surface was confirmed by flow cytometry after labeling with PE mouse anti-human CD112 and PE goat anti-mouse IgG antibodies, respectively. 2.5. Flow cytometry fischer gifhorn camping fischer germany company website