Circpvt1 review
WebApr 3, 2024 · CircPVT1 acts as a competing endogenous RNA (ceRNA) to sponge miR-181a-2-3p, promoting the expression of ESR1 and downstream ERα-target genes and … WebNov 4, 2024 · CircPVT1 (hsa_circ_0001821) is a cancer-related circular RNA (circRNA) that originated from a genomic locus on chromosome 8q24. This locus has been …
Circpvt1 review
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WebJan 28, 2024 · Here, we review circPVT1 origin and biogenesis highlighting the most important mechanisms through which it plays a fundamental role in oncogenesis, such … WebFeb 4, 2024 · Herein, we found that circPVT1 expression was significantly upregulated in HCC tissues and cell lines. Knockdown of circPVT1 significantly reduced the growth and colony formation, and increased...
WebMay 11, 2024 · This review introduces the biogenesis of circRNAs and summarizes the roles played by circRNAs in human diseases. ... circ-TTBK2 (ref. 38), and circPVT1 (ref. 39) are examples of circRNAs that act ... WebMar 1, 2024 · The expression of circPVT1 is often upregulated in GC tissues due to the amplification of its genomic locus. circPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients …
WebThis review summarizes various pathways through which PVT1 regulates the progression of cancer via miRNAs. We also propose additional regulatory mechanisms of PVT1 and their potential clinical applications. ... The circular PVT1 (circPVT1) locus is contained within the lncPVT1, which originates from the exon 2 of the PVT1 gene. Several studies ... WebCircPVT1 as potential clinical biomarker. Although studies on circPVT1 in malignancy remained scanty, significant association of the candidate with disease onset and outcome indicated it as a promising biomarker of …
WebMar 10, 2024 · A nude mouse xenograft model was used to evaluate the effects of sh‐circPVT1 and miR‐423‐5p mimics on tumor growth and metastasis in vivo. miR‐423‐5p was reduced in both OS tissues and OS cell lines, while Wnt5a/Ror2 and circPVT1 were elevated. miR‐423‐5p bound to 3′‐UTR of Wnt5a and Ror2 mRNA, and inhibited …
WebNov 2, 2024 · The Verdict: A Multi-Use Winner. While the REI Co-op DRT 1.2 is a slightly smoother, slightly larger and more trail-capable bike, it’s impossible to ignore the … inspector rutledge in orderWebApr 3, 2024 · CircPVT1 acts as a competing endogenous RNA (ceRNA) to sponge miR-181a-2-3p, promoting the expression of ESR1 and downstream ERα-target genes and … jessie dougher mayer brownWebAug 8, 2024 · The majority of studies have focused on the role of circRNAs in solid tumours, in which individual circRNAs have been described as either oncogenes (for example, circPVT1 in head and neck squamous ... jessie dobson oxfordshire county councilWebMore importantly, circPVT1 was predominantly abundant in the cytoplasm of NSCLC cells, and circPVT1 could serve as a competing endogenous RNA to regulate E2F2 expression and tumorigenesis in a miR-125b-dependent manner, which is further verified by using an in vivo xenograft model. Conclusion: jessie disney show petWebJun 29, 2024 · CircPVT1 derived from PVT1 gene is also a critical non-coding oncogenic RNA. ... (miRNAs), and/or proteins, thereby regulating a variety of cellular processes. This review summarizes the characteristics of PVT1, including their biological functions and the related mechanisms, which was the most comprehensive to date. jessie disney show bathroomWebDec 20, 2024 · Using samples from 115 HNSCC patients, we find that circPVT1 is over-expressed in tumors compared to matched non-tumoral tissues, with particular enrichment in patients with TP53 mutations. circPVT1 up- and down-regulation determine, respectively, an increase and a reduction of the malignant phenotype in HNSCC cell lines. jessi edwards superior neWebAug 1, 2024 · The levels of circPVT1 were obviously related to cumulative relapse rate and 5-year survival rate. In conclusion, our study reveals that circPVT1 participates in the … inspectorsacademy.in