WebApr 11, 2024 · HIGHLIGHTS who: Umit Aliyaskarova from the Universitu00e9 Nazarbayev University have published the paper: NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells, in the Journal: Scientific … Neil3-mediated proteasomal degradation facilitates the repair of cisplatin-induced dna … WebOct 21, 2016 · The goal was to identify the exact bases where cisplatin had added. "Owing to the ability of cisplatin-DNA adducts to stall DNA synthesis, cisplatin cross-linking …
Ixr1, a yeast protein that binds to platinated DNA and confers ...
WebThe anti-cancer drug cisplatin works to kill cells by several mechanisms. Which of the following is NOT a mechanism of cisplatin? 1.Cisplatin binds to DNA-repair enzymes … WebJan 18, 2024 · Cisplatin interacts with DNA mainly in the form of Pt-d (GpG) di-adduct, which stalls cell proliferation and activates DNA … solitary improvement in bone density
Identification of genome-wide cisplatin cross-linking sites with …
WebAug 10, 2024 · a. Kinetics of Platinum Binding to DNA. The binding of cis- and trans-DDP to DNA has been studied 67 by 195 Pt NMR spectroscopy with the use of isotopically enriched 195 Pt, which has a nuclear spin I = \(\frac{1}{2}\). The DNA used in this experiment was obtained from chicken red blood cell chromosomes that had been enzymatically … WebDec 7, 2024 · When it binds to the guanine base on the DNA molecule, a chlorine is released from cisplatin and binds to a lone pair on the guanine. Since there are two chlorines next to each other, the cisplatin can bind to two guanines next to each other and create a bond strong enough to block DNA replication. WebJul 30, 1993 · Structure-specific recognition proteins (SSRPs) bind to DNA containing intrastrand cross-links formed by the anticancer drug cisplatin. A yeast gene encoding an SSRP, designated IXR1, was cloned and sequenced. solitary housing unit