WebJan 8, 2024 · Drug–polymer miscibility is a critical parameter that has been shown to affect, for example, physical stability during storage, and dissolution rate of the final … WebDec 1, 1992 · Solid state drug-polymer miscibility studies using the model drug ABT-102. International Journal of Pharmaceutics 2016, 509 (1-2) , 285-295. DOI: 10.1016/j.ijpharm.2016.05.068. Shu Li, Yiwei Tian, David S. Jones, Gavin P. Andrews. Optimising Drug Solubilisation in Amorphous Polymer Dispersions: Rational Selection of …
Evaluation of drug-polymer miscibility in amorphous solid dispersion ...
WebMiscibility of various drugs with polymers can be explored by coupling solution theories with experimental data. These approximations provide insight into the physical stability of drug-polymer mixtures and the thermodynamic driving force for crystallization. WebDrug–polymer solid dispersion has been demonstrated as a feasible approach to formulate poorly water-soluble drugs in the amorphous form, for the enhancement of dissolution rate and bioperformance. The solubility (for crystalline drug) and miscibility (for amorphous drug) in the polymer are directly related to the stabilization of amorphous ... thin brick veneer cost
Overview of Extensively Employed Polymeric Carriers in Solid
WebNov 15, 2015 · Drug–polymer miscibility is considered to be a prerequisite to achieve an optimally performing amorphous solid dispersion (ASD). Unfortunately, it can be challenging to evaluate drug–polymer miscibility experimentally. The aim of this study was to investigate the miscibility of ASDs of itraconazole (ITZ) and hydroxypropyl … WebAug 19, 2024 · This empirical equation can provide better understanding and prediction for the miscibility and stability of drug-polymer ASD at all conditions. Keywords: Flory–Huggins interaction parameters; amorphous solid dispersion; amorphous-amorphous phase separation; binary phase diagram; drug-polymer miscibility; thermodynamic. WebThis review describes different trials to model and predict drug payload in lipid and polymeric nanocarriers. It traces the evolution of the field from the earliest attempts when numerous solubility and Flory-Huggins models were applied, to the emergence of molecular dynamic simulations and docking studies, until the exciting practically successful era of … saints best wide receivers of all time