Web26 de fev. de 2024 · A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1alpha and p53 activity in triple-negative breast cancer. Cell Death Dis. 11 , 731–743 (2024). Web11 de abr. de 2024 · 经国家自然科学基金委员会监督委员会五届十六次会议审议、国家自然科学基金委员会2024年第2次委务会议审定,决定依据《国家自然科学基金项目科研不端行为调查处理办法》(国科金发诚〔2024〕96号)第四十七条、第四十条、第四十六条,撤销张亚东国家自然科学基金项目“三维打印低氧模拟 ...
Direct Interactions between HIF-1α and Mdm2 Modulate p53 …
Web30 de nov. de 2024 · Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern. Although the incidence of this disease is increasing, there is a lack of effective therapies. In recent years, the pathogenesis of pulmonary fibrosis has become a research hotspot. p53 is a tumor suppressor gene with crucial roles in cell … WebThe HIF-1a/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization. J Cell Mol Med 25:1700-1711 (2024). PubMed: 33438362; Charruyer A et al. Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis. Aging Cell … small world learning center gresham
P53 and Cancer-Associated Fibroblasts
Web7 de jul. de 2024 · How HIF-1α and p53 dynamics vary and what the underlying mechanism of their reciprocal regulation will be clarified in the following. Regulation of HIF-1α dynamics by PHD-2. As shown in Fig. 2A, HIF-1α shows adaptive behavior and sustained high levels under mild and moderate hypoxia, respectively. Web8 de set. de 2015 · Both the hypoxia-inducible factor-1 (HIF-1) and tumor suppressor p53 are involved in the cellular response to hypoxia. How the two transcription factors interact … Web2 de out. de 2024 · Due to the EC-specific distribution and expression of HIF-2α in the lungs, combination therapy with the HIF-2α antagonist PT2385 and the p53 agonist Nutlin3a can effectively reduce the Nutlin3a-induced increase of p53 in PAECs and, subsequently, inhibit PAEC apoptosis, without affecting the Nutlin3a-induced increase of p53 and its anti … small world learning center farmington