Incidence of thrombocytopenia with daptomycin

Author: lavw

August undefined, 2024

WebFirst, the time from daptomycin initiation to the diagnosis of thrombocytopenia was 4 days. Drug-dependent antiplatelet antibodies usually develop only after 1 to 2 weeks of drug exposure ( 1 ). However, the rapid drop in the patient's platelet count strongly suggests immune-mediated thrombocytopenia. WebThrombocytopenia is found among people who take Daptomycin, especially for people who are male, 60+ old, have been taking the drug for < 1 month. The phase IV clinical study …

A Case of Daptomycin-Induced Immune Thrombocytopenia

WebNov 30, 2024 · Thrombocytopenia can occur in 10% to 30% of patients treated with heparin in the absence of an obvious involvement of the immune system. The underlying pathophysiology is thought to be mediated by direct binding of heparin to platelets, resulting in mild platelet activation. sokyu no fanfare lyrics

RACGP - Incidentally detected thrombocytopaenia in …

WebFeb 1, 2024 · Incidence not known Agitation blindness blistering, peeling, or loosening of the skin blurred vision burning, numbness, tingling, or painful sensations coma decreased vision depression eye pain general feeling of discomfort hives, itching hostility irritability joint pain WebNov 23, 2024 · Common side effects of daptomycin may include: chest pain, trouble breathing; headache, dizziness; stomach pain, vomiting; swelling; abnormal liver function tests; rash, itching, sweating; trouble sleeping; sore throat; or increased blood pressure. This is not a complete list of side effects and others may occur. Webcytopenia, especially thrombocytopenia; alternative therapy should be considered in patients with thrombocytopenia. Linezolid should be used with caution in patients on medications with serotonergic activity, e.g., SSRI and MAOI. See SSRI & Linezolid Education. Daptomycin may replace linezolid if no epidural extension of infection is present. slug sidewall puncture repair kit

Daptomycin versus linezolid for treatment of vancomycin-resistant …

Daptomycin and Thrombocytopenia, a phase IV clinical study of …

WebThe incidence of drug-induced thrombocytopenia is not well defined, in part because reporting is voluntary and is not critically reviewed. On the basis of several epidemiologic studies in the ... Webthe patient was initiated on daptomycin 6 mg/kg (300 mg) daily in response to wound cultures detecting Enterococcus faecium susceptible only to daptomycin and linezolid. Starting 96 hours after daptomycin initiation, there was a profound reduction in the patient’s WBC, reaching a nadir of 1.63 x 10-3 /µL after 12 days of therapy. Prior to ... sokyo the starWebNational Center for Biotechnology Information sokyu no fanfare english lyrics

"WebThe profound thrombocytopenia prompted us to stop piperacillin-tazobactam, daptomycin, and heparin. No effect was seen after intravenous immunoglobulin and corticosteroid … " - Incidence of thrombocytopenia with daptomycin

Incidence of thrombocytopenia with daptomycin

A Case of Daptomycin-Induced Immune Thrombocytopenia

WebMar 11, 2024 · Thrombocytopenia is an abnormally low level of platelets in the blood. Platelets are made by the bone marrow. They help your blood to clot. People with … WebOct 1, 2012 · described case of daptomycin-induced thrombocytopenia. W e report a case of daptomycin-induced immune thrombo- cytopenia observed in a 64-year-old man admitted …

Did you know?

WebThe reported incidence of drug-induced thrombocytopenia (DIT) is 10 cases per 1 million people per year, but the number is presumed to be higher because of underreporting and … WebMay 15, 2015 · To our knowledge, this is the first described case of daptomycin-induced thrombocytopenia. View. ... Although the incidence is low, more than 100 drugs have been implicated in thrombocytopenia ...

WebApr 13, 2024 · Daptomycin has good skin and soft tissue penetration (reaching concentrations of approximately 70–90% of the free drug in the plasma) and concentrates in the urinary system (54% of the drug is excreted in its active form) . Unlike linezolid, daptomycin has poor CSF penetration and therefore is not an ideal antibiotic for … WebJun 1, 2024 · In the subset of studies focusing on high-dose daptomycin, patients receiving daptomycin tended to show a higher clinical response rate (OR 1.61; 95% CI 0.37–7.09; I2 …

WebJun 15, 2006 · The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. Published case reports have documented the presence of myopathy in patients who received daptomycin; however, there have been no previously reported cases of rhabdomyolysis in … WebDec 13, 2014 · Subgroup analysis of studies that reported aORs indicated that daptomycin was associated with higher mortality (OR: 1.59, 95% CI: 1.02–2.50, p = 0.04). There was no evidence of publication bias, but all enrolled studies were retrospective, had small sample sizes, and had substantial limitations. Conclusions

WebNov 15, 2016 · Drug-induced thrombocytopenia (DIT) has been reported as an adverse reaction of over 300 medications [ 1, 2 ]. Nearly ten cases per 1,000,000 patients develop DIT annually. Results of limited epidemiological studies could not identify the probable risk factors for DIT [ 3 ].

WebApr 14, 2024 · Heparin-induced thrombocytopenia (HIT) is a major complication of the administration of heparin and can result in life-threatening thrombosis with or without thrombocytopenia (HIT-T) or can produce thrombocytopenia without clinically symptomatic thrombosis (“isolated” HIT). slugs in compost binWebMar 23, 2024 · Introduction: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus (SFTSV), which has a high fatality rate. This disease has become increasingly prevalent in recent years in Jiangsu province, with a noticeable rise in its incidence. Notably, fatal cases have also been increasing. soky rescue thomasWebJun 1, 2024 · Drug-induced thrombocytopenia (DITP) is an adverse reaction that has been reported with more than 300 medications, most commonly due to drug-dependent platelet antibodies that produce a response from the reticuloendothelial system [1, 2 ]. slugs in conservatoryWebSep 7, 2024 · Daptomycin (DAP), a cyclic lipopeptide, ... Given the current low incidence of DAP-R among S. epidermidis in the United States, DAP susceptibility is not universally reported by clinical microbiology laboratories and may often only be inferred. However, increasing reports of DAP-NS CoNS isolates raise the importance of vigilant monitoring … soky wild onesWebConclusions: Compared with linezolid treatment, daptomycin treatment showed comparable clinical and microbiological outcomes but a lower incidence of thrombocytopenia. … slugs inf crossword clueWebOct 21, 2024 · Citation 148 Weigelt et al found the incidence of reported thrombocytopenia (level not defined) was statistically more common in 592 patients receiving linezolid ... and vancomycin were USD $18,057, $20,698, and $23,671, respectively. The cost-effectiveness ratios for linezolid, daptomycin, and vancomycin were calculated to be $37,604, $44,086 ... sokyo the star sydneyWebThrombocytopaenia, but not neutropaenia, is described as a possible or probable adverse effect in the product information. Up to now, two case reports of daptomycin-induced … sokyo trading hours