Phospholipidosis toxicity
WebThe recent accumulation of toxicity-associated gene sets (toxicogenomic biomarkers), enrichment in public or commercial large-scale microarray database and availability of open-source software resources facilitate our utilization of the toxicogenomic data. ... [14,15], phospholipidosis [16,17] and glutathione depletion [18,19]. These TGx ... WebAug 16, 2004 · FDA Phospholipidosis Guidance Being Developed; Toxicity Is Concern 16 Aug 2004 News The Pink Sheet [email protected] Executive Summary FDA is planning to develop a guidance on phospholipidosis issues in drug products You may also be interested in... Sepracor Soltara “not approvable”
Phospholipidosis toxicity
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WebDec 1, 2003 · The most serious potential adverse effect of amiodarone therapy is pulmonary toxicity, which may result from direct drug-induced phospholipidosis or immune-mediated hypersensitivity. 19 The most ... WebAug 18, 2024 · Drug-induced phospholipidosis is a phospholipid storage condition characterized by excess accumulation of membranous lamellar structures in cells. 1 – 3 Over 200 marketed drugs and drug candidates have been shown to induce phospholipidosis in animal studies.
WebPhospholipidosis Skin and Respiratory Sensitization Endocrine Toxicity Reproductive Toxicity Models of Environmental Toxicity References This website uses cookies We use cookies to enhance your browsing experience and analyze our traffic. WebPhospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues. [1] [2] [3] Certain cases may be triggered by medications. [4] …
WebFeb 7, 2011 · A basic understanding of this process, which leads to hematopoietic cellular differentiation and release of these cells into the circulation, is important to accurately interpret the changes in bone marrow and blood that may be seen in nonclinical toxicity studies. Regulatory Guidelines for Bone Marrow Evaluation Webphospholipidosis seem to be protected from the toxic effects of intratracheal silica (Environ. Health Perspec 102:327-378). Phospholipidosis was generally ameliorated after a drug-free period, but in some cases the changes were not completely reversed at the end of a three month drug-free study period. Phospholipidosis is not unique to posaconazole
WebMay 1, 2024 · The deposits might be associated with drug-induced phospholipidosis or other mechanisms, for instance, lysosomal sequestration, drug precipitation, or toxicity to the epithelium. Differentiation of the etiology can be complicated by the similarities of these conditions to corneal deposits due to genetic causes or systemic conditions (Fabry ...
WebPhospholipidosis is a lysosomal storage disorder characterized by the excess accumulation of phospholipids in tissues, often stimulated by drugs. Drug induced hepatotoxicity is a leading cause of attrition during drug development. smart goal strategyWebAug 18, 2024 · Drug-induced phospholipidosis is a phospholipid storage condition characterized by excess accumulation of membranous lamellar structures in cells. 1 – 3 Over 200 marketed drugs and drug candidates have been shown to induce phospholipidosis in animal studies. hills pavingWebPhospholipidosis is a distinct form of lipidosis caused by amphiphilic drugs such as chlorphentermine. These toxins bind to phospholipids and inhibit their catabolism. … hills partnership limitedWebAug 16, 2004 · FDA Phospholipidosis Guidance Being Developed; Toxicity Is Concern 16 Aug 2004 News The Pink Sheet [email protected] Executive Summary FDA is … smart goal setting for career developmentWebJul 8, 2014 · Steatosis, steatohepatitis, and phospholipidosis: Steatosis secondary to drug toxicity may be in the form of medium-sized and large droplets (macrovesicular) or small … smart goal setting google scholarWebDrug toxicity, often manifested as liver toxicity and cardiotoxicity, is a key reason for drug attrition. Identifying potential toxicity at an early stage in drug discovery can save both time and developmental costs, and most importantly reduce the likelihood of late stage failure. ... drug-induced phospholipidosis and steatosis, lysosomal ... smart goal planner worksheetWebThe HCS LipidTOX™ Red phospholipidosis detection reagent was developed to characterize the potentially toxic side effects of compounds on lipid metabolism in mammalian cell lines. This reagent is easily detected by fluorescence microscopy or an HCS reader equipped with filters that can detect excitation/emission maxima ∼595/615 nm. hills panels beighton